Physician Resources
Help patients and parents understand ADHD and have the best experience possible with Daytrana. From diagnosis through treatment, the following resources can help make it easier to manage ADHD symptoms:
Medscape ADHD Condition Site
The Medscape ADHD Condition Site sponsored by Shire includes articles on important topics in ADHD, including discussions with ADHD thought leaders. Medscape registration is required.
Medscape ADHD Franchise Site
The Medscape ADHD Franchise Site sponsored by Shire is a comprehensive resource for information on Shire ADHD treatments, publications, and clinical information. Medscape registration is required.
American Psychological Association
The latest on ADHD news, studies, and treatments from the American Psychological Association (APA) Online.
Psychiatry Online
PsychiatryOnline.com offers a collection of psychiatric references—including books and journals—on ADHD and other psychiatric disorders. You can get instant access to references, journals, self-assessment tools, and clinical and research news.
eMedicine
eMedicine, from WebMD, is the largest and most current clinical knowledge base available to physicians and other healthcare professionals. The ADHD resource center within eMedicine, features patient education materials, PDA and newsletter downloads, journal abstracts, and other valuable ADHD-related resources for Physicians in a conveniently organized manner.
For Your Patients
ADHDSupport.com
Provides ADHD facts, and features tools and resources designed for multiple patient types.
About: ADD/ADHD
Suggestions and tips for parents working with preschool children with ADD/ADHD.
ADHDNews.com
ADHDNews.com is a community started by Brandi Valentine in 1995. This site contains the latest information about ADHD and links to ADHD support networks for parents.
Healthyplace.com
User-friendly site that provides support, information, and friendship for both parents and children with ADHD.
Children and Adults with Attention-Deficit/Hyperactivity Disorder (CHADD)
Children and Adults with Attention-Deficit/Hyperactivity Disorder (CHADD) is a national nonprofit, tax-exempt (Section 501 (c) (3)) organization providing education, advocacy, and support for individuals with ADHD.
NewIdeas.net
Comprehensive resources for both parents and teachers, providing education and creative ideas for classroom use.
Surgeon General Website
Report of the Surgeon General addressing ADHD in children. A good resource for facts and figures.
INDICATION
Daytrana is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children (ages 6-12) and adolescents (ages 13-17). The efficacy of Daytrana was established in controlled clinical studies: two 7-week trials in children and one 7-week trial in adolescents. Daytrana is indicated as an integral part of a total treatment program for ADHD that may include other measures (psychological, educational, and social).
IMPORTANT SAFETY INFORMATION
WARNING: DRUG DEPENDENCE
Daytrana should be given cautiously to patients with a history of drug dependence or alcoholism. Chronic abusive use can lead to marked tolerance and psychological dependence with varying degrees of abnormal behavior. Frank psychotic episodes can occur, especially with parenteral abuse. Careful supervision is required during withdrawal from abusive use, since severe depression may occur. Withdrawal following chronic therapeutic use may unmask symptoms of the underlying disorder that may require follow-up.
Daytrana should not be used in patients who have an allergy to methylphenidate or other patch components; marked anxiety, tension, and agitation; glaucoma; motor tics or with a diagnosis or a family history of Tourette’s syndrome; seizures; are being treated (or within 14 days after treatment) with monoamine oxidase inhibitors (MAOIs).
Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems.
Sudden death, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD. A careful patient history, including family history, and physical exam should be performed to assess the presence of cardiac disease. Stimulant products generally should not be used in patients with known structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, or other serious heart problems. Patients who develop symptoms (ie, exertional chest pain, unexplained syncope) suggestive of cardiac disease while taking Daytrana should be promptly evaluated. Use with caution in patients whose underlying medical condition might be affected by increases in blood pressure or heart rate. Use cautiously with pressor agents. Hematologic monitoring is advised during prolonged treatment.
Use with caution in patients with a history of psychosis, EEG abnormalities, bipolar disorder, and depression. New psychosis, mania, aggression, visual disturbances, and growth suppression have been associated with the use of stimulants. Growth should be monitored in children during treatment with stimulants, and patients who are not growing (gaining height or weight) as expected may need to have their treatment interrupted.
Use of Daytrana may lead to contact sensitization. Erythema has been commonly reported and is not by itself an indication of sensitization. If contact sensitization is suspected (erythema with edema, papules and/or vesicles spread beyond the patch site and/or lack of improvement within 48 hours), treatment should be discontinued. Patients should avoid applying external heat to the Daytrana patch; application of heat can increase the extent and rate of absorption.
The most common adverse reactions associated with Daytrana (at least 5% and twice the rate of placebo-treated patients) in clinical trials were: children – decreased appetite, insomnia, nausea, vomiting, decreased weight, tics, affect lability, and anorexia; adolescents – decreased appetite, nausea insomnia, decreased weight, dizziness, abdominal pain and anorexia. In addition, the majority of subjects in these studies had minimal to definite skin erythema at the patch application site. Leaving the patch on for longer than the recommended 9 hours has resulted in an increased incidence of adverse events.
Please see Full Prescribing Information, including Boxed Warning regarding Drug Dependence.
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Daytrana® is a registered trademark of Shire Pharmaceuticals Ireland Limited.
DAY-00507 07/10
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